You can use ./build.sh to configure and build with default options. It is advised to run ./autogen.sh before ./configure (autoconf and automake need to be installed on your system for autogen.sh to work) ./configure has an option named --with-cuda that allows you to specify where your CUDA 6.5 toolkit is installed (usually /usr/local/cuda, but some distros may have a different default location) ** How to compile on Fedora 22 (2015) ** # Step 1: gcc and dependencies dnf install gcc gcc-c++ automake dnf install jansson-devel openssl-devel libcurl-devel zlib-devel pciutils-devel # Step 2: nvidia drivers (Download common linux drivers from nvidia site) dnf install kernel-devel modprobe -r nouveau ./NVIDIA-Linux-x86_64-346.72.run # Step 3: CUDA SDK (Download from nvidia archive) dnf install cuda-repo-fedora20-6-5-prod-6.5-19.x86_64.rpm dnf install cuda-minimal-build-6-5.x86_64 # add the nvcc binary path to the system ln -s /usr/local/cuda-6.5 /usr/local/cuda echo 'export PATH=$PATH:/usr/local/cuda/bin' > /etc/profile.d/cuda.sh # add the cudart library path to the system echo /usr/local/cuda/lib64 > /etc/ld.so.conf.d/cuda.conf ldconfig # Step 4: Fix the toolkit warning with gcc 5.1 edit the file /usr/local/cuda/include/host_config.h and comment/delete the line 82 : #error -- unsupported GNU version! gcc 4.9 ./build.sh ./ccminer -n ** How to compile on macOS ** # Step 1: download and install CUDA Toolkit 8 or more recent # https://developer.nvidia.com/cuda-toolkit-archive # Step 2: install Homebrew ruby -e "$(curl -fsSL https://raw.githubusercontent.com/Homebrew/install/master/install)" # Step 3: dependencies brew install pkg-config autoconf automake curl openssl llvm ./build.sh ./ccminer -n